Version 5.4
Mus musculus Gene: Arap2
Summary
InnateDB Gene IDBG-165165.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arap2
Gene Name ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000037999
Encoded Proteins
IDBP-165167
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
IDBP-532708
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
IDBP-535539
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
IDBP-533448
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000047365:
The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:62602445-62766198
Strand Reverse strand
Band C3.1
Transcripts
ENSMUST00000076623 ENSMUSP00000075924
ENSMUST00000160620
ENSMUST00000159022 ENSMUSP00000125391
ENSMUST00000160419
ENSMUST00000161911 ENSMUSP00000124827
ENSMUST00000159470 ENSMUSP00000124743
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0007165 signal transduction
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000047365
View Gene Order
ENSBTAG00000039922
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
arf6_pathway
Arf6 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.244403 Mm.394905
RefSeq NM_178407 XM_006503830
OMIM
CCDS CCDS51506
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca