Version 5.4
Mus musculus Gene: Osm
Summary
InnateDB Gene IDBG-142284.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Osm
Gene Name oncostatin M
Synonyms OncoM
Species Mus musculus
Ensembl Gene ENSMUSG00000058755
Encoded Proteins
IDBP-142286
oncostatin M
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25692402
Stat3 is required for maximal Osm-induced lung Cxcl5 expression and subsequent neutrophil recruitment during bacterial pneumonia.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099985:
Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:4236420-4241026
Strand Forward strand
Band A1
Transcripts
ENSMUST00000075221 ENSMUSP00000074708
ENSMUST00000131764
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005147 oncostatin-M receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0006955 immune response
GO:0007422 peripheral nervous system development
GO:0008284 positive regulation of cell proliferation
GO:0009408 response to heat
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0040008 regulation of growth
GO:0042503 tyrosine phosphorylation of Stat3 protein
GO:0042506 tyrosine phosphorylation of Stat5 protein
GO:0042508 tyrosine phosphorylation of Stat1 protein
GO:0043410 positive regulation of MAPK cascade
GO:0045087 innate immune response (InnateDB)
GO:0045835 negative regulation of meiosis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046888 negative regulation of hormone secretion
GO:0048266 behavioral response to pain
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005900 oncostatin-M receptor complex
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000099985
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_114
Oncostatin_M pathway
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
il3_pathway
IL3-mediated signaling events
gmcsf_pathway
GMCSF-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.131422 Mm.416058
RefSeq NM_001013365
OMIM
CCDS CCDS24382
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca