Version 5.4
Mus musculus Gene: Skp2
Summary
InnateDB Gene IDBG-128953.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Skp2
Gene Name S-phase kinase-associated protein 2 (p45)
Synonyms 4930500A04Rik; FBXL1; FWD1; p45
Species Mus musculus
Ensembl Gene ENSMUSG00000054115
Encoded Proteins
IDBP-128955
S-phase kinase-associated protein 2 (p45)
IDBP-259952
S-phase kinase-associated protein 2 (p45)
IDBP-788435
S-phase kinase-associated protein 2 (p45)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 27194766
[Homo sapiens] IFI27 restricts viral infection by recruiting an E3 ligase, SKP2, for ubiquitination and degradation of viral protein.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145604:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:9111985-9155425
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000096482 ENSMUSP00000094225
ENSMUST00000110585 ENSMUSP00000106215
ENSMUST00000190131 ENSMUSP00000139997
ENSMUST00000191316
ENSMUST00000190406
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 114 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 114 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000209 protein polyubiquitination
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051726 regulation of cell cycle
GO:0071460 cellular response to cell-matrix adhesion
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016235 aggresome
GO:0019005 SCF ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145604
View Gene Order
ENSBTAG00000013562
Not yet available
Pathways
NETPATH
REACTOME
REACT_249770
Cell Cycle, Mitotic pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_260005
G1 Phase pathway
REACT_223647
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_188804
Cell Cycle pathway
REACT_244364
APC/C-mediated degradation of cell cycle proteins pathway
REACT_230745
Immune System pathway
REACT_258573
Cyclin D associated events in G1 pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_226135
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_254995
Regulation of mitotic cell cycle pathway
REACT_253002
G1/S Transition pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_229531
Adaptive Immune System pathway
REACT_245868
Cyclin E associated events during G1/S transition pathway
REACT_220647
SCF(Skp2)-mediated degradation of p27/p21 pathway
REACT_253623
S Phase pathway
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04110
Cell cycle pathway
mmu05222
Small cell lung cancer pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_3
Notch pathway
REACTOME
REACT_6761
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_9003
SCF(Skp2)-mediated degradation of p27/p21 pathway
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_1590
G1 Phase pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04110
Cell cycle pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa05222
Small cell lung cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
foxopathway
FoxO family signaling
p53regulationpathway
p53 pathway
myc_pathway
C-MYC pathway
foxm1pathway
FOXM1 transcription factor network
notch_pathway
Notch signaling pathway
Cross-References
SwissProt Q9Z0Z3
TrEMBL
UniProt Splice Variant
Entrez Gene 27401
UniGene Mm.35584 Mm.413351
RefSeq NM_145468 NM_001285980 NM_013787
OMIM
CCDS CCDS37037
HPRD
IMGT
MGI ID MGI:1351663
MGI Symbol Skp2
EMBL AF083215 AK032979 AK037002 AK044212 BC003468
GenPept AAD16037 AAH03468 BAC28108 BAC31819
RNA Seq Atlas 27401

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca