InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPY

Summary

InnateDB Protein

IDBP-9839.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPY

Protein Name

neuropeptide Y

Synonyms

PYY4;

Species

Homo sapiens

Ensembl Protein

ENSP00000242152

InnateDB Gene

IDBG-9837 (NPY)

Protein Structure

UniProt Annotation

Function

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005184	neuropeptide hormone activity
GO:0005246	calcium channel regulator activity

Biological Process

GO:0006816	calcium ion transport
GO:0006928	cellular component movement
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007218	neuropeptide signaling pathway
GO:0007268	synaptic transmission
GO:0007586	digestion
GO:0007610	behavior
GO:0007631	feeding behavior
GO:0008015	blood circulation
GO:0008283	cell proliferation
GO:0008343	adult feeding behavior
GO:0021954	central nervous system neuron development
GO:0021987	cerebral cortex development
GO:0031175	neuron projection development
GO:0032100	positive regulation of appetite