InnateDB Protein
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IDBP-9815.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EIF3J
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Protein Name
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eukaryotic translation initiation factor 3, subunit J
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Synonyms
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eIF3-alpha; eIF3-p35; EIF3S1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000261868
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InnateDB Gene
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IDBG-9813 (EIF3J)
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Protein Structure
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Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
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Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03009}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
35
[view]
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Protein-Protein |
35
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR013906
Eukaryotic translation initiation factor 3 subunit J
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PFAM |
PF08597
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75822
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PhosphoSite |
PhosphoSite-O75822
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TrEMBL |
A0A024R5S5
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UniProt Splice Variant |
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Entrez Gene |
8669
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UniGene |
Hs.735826
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RefSeq |
NP_003749
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HUGO |
HGNC:3270
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OMIM |
603910
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CCDS |
CCDS10111
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HPRD |
04883
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IMGT |
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EMBL |
AC009996
AF090923
AK023388
AK300659
BC002719
CH471082
CR606839
U97670
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GenPept |
AAC78729
AAF24039
AAH02719
BAB14555
BAG62345
EAW77268
EAW77270
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