InnateDB Protein
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IDBP-9629.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GPNMB
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Protein Name
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glycoprotein (transmembrane) nmb
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Synonyms
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HGFIN; NMB;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000371420
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InnateDB Gene
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IDBG-9627 (GPNMB)
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Protein Structure
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Function |
Could be a melanogenic enzyme. {ECO:0000250}.
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Subcellular Localization |
Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Detected at the cell surface in different types of cancers cells, including glioblastoma multiforme cells and most melanoma cell lines.
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Disease Associations |
Note=Glioblastoma multiforme patients that exhibit increased mRNA and protein levels (>3-fold over normal brain) in biopsy samples have a significantly higher risk of death (PubMed:16609006). In the context of cancer immunotherapy, including that of melanoma, has been proposed to be used as a cell surface protein antigen targeted by antibodies coupled to cytotoxic drugs (PubMed:16489096). {ECO:0000269PubMed:16489096, ECO:0000269PubMed:16609006}.
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Tissue Specificity |
Up-regulated in various cancer cells, including in glioblastoma multiforme. Expressed in many melanoma cells, as well as in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level). Hardly detectable in healthy brain. {ECO:0000269PubMed:16489096, ECO:0000269PubMed:16609006, ECO:0000269PubMed:7814155}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000601
PKD domain
IPR022409
PKD/Chitinase domain
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PFAM |
PF00801
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PRINTS |
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PIRSF |
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SMART |
SM00089
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TIGRFAMs |
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Modification |
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SwissProt |
Q14956
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PhosphoSite |
PhosphoSite-Q14956
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10457
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UniGene |
Hs.639968
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RefSeq |
NP_001005340
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HUGO |
HGNC:4462
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OMIM |
604368
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CCDS |
CCDS34610
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HPRD |
05081
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IMGT |
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EMBL |
AC005082
AF322909
AY359124
BC032783
CH236948
CH471073
X76534
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GenPept |
AAG42839
AAH32783
AAP22336
AAQ89481
CAA54044
EAL24259
EAW93782
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