InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMPRSS15

Summary

InnateDB Protein

IDBP-962.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMPRSS15

Protein Name

transmembrane protease, serine 15

Synonyms

ENTK; PRSS7;

Species

Homo sapiens

Ensembl Protein

ENSP00000284885

InnateDB Gene

IDBG-960 (TMPRSS15)

Protein Structure

UniProt Annotation

Function

Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Enterokinase deficiency (ENTKD) [MIM:226200]: Life- threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive. {ECO:0000269PubMed:11719902}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Intestinal brush border.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0006898	receptor-mediated endocytosis

Cellular Component

GO:0005903	brush border
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000082 SEA domain
IPR000859 CUB domain
IPR000998 MAM domain
IPR001190 SRCR domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel
IPR017448 SRCR-like domain

PFAM