InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SREBF2

Summary

InnateDB Protein

IDBP-9450.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SREBF2

Protein Name

sterol regulatory element binding transcription factor 2

Synonyms

bHLHd2; SREBP-2; SREBP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000354476

InnateDB Gene

IDBG-9448 (SREBF2)

Protein Structure

UniProt Annotation

Function

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.Processed sterol regulatory element-binding protein 2: Nucleus.

Disease Associations

Tissue Specificity

Ubiquitously expressed in adult and fetal tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	73 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006629	lipid metabolic process
GO:0008203	cholesterol metabolic process
GO:0010886	positive regulation of cholesterol storage
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0055098	response to low-density lipoprotein particle stimulus
GO:0071499	cellular response to laminar fluid shear stress
GO:0072368	regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
GO:0090370	negative regulation of cholesterol efflux
GO:2000188	regulation of cholesterol homeostasis

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0032937	SREBP-SCAP-Insig complex