InnateDB Protein
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IDBP-9309.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AFAP1
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Protein Name
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actin filament associated protein 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000353402
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InnateDB Gene
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IDBG-9307 (AFAP1)
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Protein Structure
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Function |
Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269PubMed:15485829}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:15485829}. Note=Localizes with stress fibers in quiescent cells, concentrated in cell motility structures such as lamellipodia, filopodia and membrane ruffles upon their induction.
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Disease Associations |
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Tissue Specificity |
Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF- 7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma. {ECO:0000269PubMed:17520695, ECO:0000269PubMed:17885682}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001849
Pleckstrin homology domain
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PFAM |
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N556
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PhosphoSite |
PhosphoSite-Q8N556
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
60312
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UniGene |
Hs.529369
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RefSeq |
XP_006713972
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HUGO |
HGNC:24017
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OMIM |
608252
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CCDS |
CCDS3397
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HPRD |
09747
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IMGT |
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EMBL |
AB209676
AC004169
AC097381
AC112254
AC141931
AC144451
AF188700
AK290807
AK297631
BC032777
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GenPept |
AAG17055
AAH32777
BAD92913
BAF83496
BAG60004
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