InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NME3

Summary

InnateDB Protein

IDBP-9257.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NME3

Protein Name

non-metastatic cells 3, protein expressed in

Synonyms

c371H6.2; DR-nm23; NDPK-C; NDPKC; NM23-H3; NM23H3;

Species

Homo sapiens

Ensembl Protein

ENSP00000219302

InnateDB Gene

IDBG-9255 (NME3)

Protein Structure

UniProt Annotation

Function

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0006165	nucleoside diphosphate phosphorylation
GO:0006183	GTP biosynthetic process
GO:0006228	UTP biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0006915	apoptotic process