InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKAP5

Summary

InnateDB Protein

IDBP-9128.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKAP5

Protein Name

A kinase (PRKA) anchor protein 5

Synonyms

AKAP75; AKAP79; H21;

Species

Homo sapiens

Ensembl Protein

ENSP00000315615

InnateDB Gene

IDBG-9126 (AKAP5)

Protein Structure

UniProt Annotation

Function

May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.

Subcellular Localization

Membrane {ECO:0000269PubMed:21771783}; Lipid-anchor {ECO:0000269PubMed:21771783}. Note=Associates with lipid rafts.

Disease Associations

Tissue Specificity

Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008179	adenylate cyclase binding
GO:0051018	protein kinase A binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006605	protein targeting
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0010739	positive regulation of protein kinase A signaling
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion