InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ST13

Summary

InnateDB Protein

IDBP-8877.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ST13

Protein Name

suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)

Synonyms

AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP; HSPABP1; P48; PRO0786; SNC6;

Species

Homo sapiens

Ensembl Protein

ENSP00000216218

InnateDB Gene

IDBG-8875 (ST13)

Protein Structure

UniProt Annotation

Function

One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.

Experimentally validated
Total	46 [view]
Protein-Protein	43 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0030544	Hsp70 protein binding
GO:0030674	protein binding, bridging
GO:0032403	protein complex binding
GO:0032564	dATP binding
GO:0042802	identical protein binding
GO:0051082	unfolded protein binding
GO:0051087	chaperone binding

Biological Process

GO:0006457	protein folding
GO:0051260	protein homooligomerization
GO:0061084	negative regulation of protein refolding
GO:0070389	chaperone cofactor-dependent protein refolding

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001440 Tetratricopeptide TPR1
IPR006636 Heat shock chaperonin-binding
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00727
SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P50502