InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL17RA

Summary

InnateDB Protein

IDBP-887.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL17RA

Protein Name

interleukin 17 receptor A

Synonyms

CANDF5; CD217; CDw217; hIL-17R; IL-17RA; IL17R;

Species

Homo sapiens

Ensembl Protein

ENSP00000320936

InnateDB Gene

IDBG-885 (IL17RA)

Protein Structure

UniProt Annotation

Function

Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. {ECO:0000269PubMed:19838198, ECO:0000269PubMed:21993848}.

Subcellular Localization

Isoform 1: Membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}.Isoform 2: Secreted.

Disease Associations

Candidiasis, familial, 5 (CANDF5) [MIM:613953]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269PubMed:21350122}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:21993848}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030368	interleukin-17 receptor activity

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0019221	cytokine-mediated signaling pathway
GO:0032747	positive regulation of interleukin-23 production
GO:0071345	cellular response to cytokine stimulus
GO:0072537	fibroblast activation
GO:1900017	positive regulation of cytokine production involved in inflammatory response