Version 5.4
Homo sapiens Protein: GRAP2
Summary
InnateDB Protein IDBP-8578.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRAP2
Protein Name GRB2-related adaptor protein 2
Synonyms GADS; GRAP-2; GRB2L; GRBLG; GrbX; Grf40; GRID; GRPL; Mona; P38;
Species Homo sapiens
Ensembl Protein ENSP00000339186
InnateDB Gene IDBG-8576 (GRAP2)
Protein Structure
UniProt Annotation
Function Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
Subcellular Localization Nucleus {ECO:0000269PubMed:21179510}. Cytoplasm {ECO:0000269PubMed:21179510}. Endosome {ECO:0000269PubMed:21179510}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0007265 Ras protein signal transduction
GO:0007267 cell-cell signaling
GO:0009967 positive regulation of signal transduction
GO:0031295 T cell costimulation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
IPR001452 SH3 domain
IPR011511 Variant SH3 domain
PFAM PF00017
PF14633
PF00018
PF14604
PF07653
PRINTS PR00401
PR00452
PIRSF
SMART SM00252
SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75791
PhosphoSite PhosphoSite-O75791
TrEMBL Q6FI14
UniProt Splice Variant
Entrez Gene 9402
UniGene Hs.599494
RefSeq NP_004801
HUGO HGNC:4563
OMIM 604518
CCDS CCDS13999
HPRD 05156
IMGT
EMBL AF042380 AF090456 AF102694 AF121002 AF129476 AF236119 AF236120 AJ011736 AK303280 AK303470 AK312830 AY069959 BC025692 BC026002 CH471095 CR456498 CR536524 Y18051 Z82206
GenPept AAC69273 AAD04926 AAD13027 AAD41782 AAF31758 AAF60319 AAF60320 AAH25692 AAH26002 AAL58573 BAG35685 BAH13929 BAH13969 CAA09757 CAA77021 CAG30384 CAG38761 CAI42713 EAW60356 EAW60359

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca