InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAT2

Summary

InnateDB Protein

IDBP-812918.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAT2

Protein Name

linker for activation of T cells family, member 2

Synonyms

LAB; NTAL; WBSCR15; WBSCR5; WSCR5;

Species

Homo sapiens

Ensembl Protein

ENSP00000483925

InnateDB Gene

IDBG-21069 (LAT2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042169	SH2 domain binding

Biological Process

GO:0019722	calcium-mediated signaling
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042113	B cell activation
GO:0043303	mast cell degranulation
GO:0045087	innate immune response
GO:0050853	B cell receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0042629	mast cell granule
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AC005081 AF045555 AF161531 AF252611 AF252612 AF252613 AF252614 AF257135 AK002099 AK092904 AK290074 AK290916 AY190023 BC001609 BC009204 CH471200

GenPept

AAF29018 AAF74978 AAF91352 AAH01609 AAH09204 AAK37429 AAK37430 AAK37431 AAK37633 AAO63155 AAS07404 AAS07405 BAA92084 BAF82763 BAF83605 BAG52627 EAW69610 EAW69611 EAW69612 EAW69613

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca