InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NRIP1

Summary

InnateDB Protein

IDBP-790.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRIP1

Protein Name

nuclear receptor interacting protein 1

Synonyms

RIP140;

Species

Homo sapiens

Ensembl Protein

ENSP00000327213

InnateDB Gene

IDBG-788 (NRIP1)

Protein Structure

UniProt Annotation

Function

Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. {ECO:0000269PubMed:10364267, ECO:0000269PubMed:11509661, ECO:0000269PubMed:11518808, ECO:0000269PubMed:12554755, ECO:0000269PubMed:15060175, ECO:0000269PubMed:7641693}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11266503, ECO:0000269PubMed:12773562, ECO:0000269PubMed:15060175, ECO:0000269PubMed:7641693}. Note=Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand- bound NR3C1.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	85 [view]
Protein-Protein	80 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0030331	estrogen receptor binding
GO:0035257	nuclear hormone receptor binding
GO:0035259	glucocorticoid receptor binding
GO:0050681	androgen receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0030521	androgen receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter