Homo sapiens Protein: EDC3
Summary
InnateDB Protein IDBP-744705.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EDC3
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000455580
InnateDB Gene IDBG-22430 (EDC3)
Protein Structure
UniProt Annotation
Function Binds single-stranded RNA. In the process of mRNA degradation, may play a role in mRNA decapping. May play a role in spermiogenesis and oogenesis. {ECO:0000269PubMed:16364915, ECO:0000269PubMed:17533573, ECO:0000269PubMed:18678652}.
Subcellular Localization Cytoplasm, P-body {ECO:0000269PubMed:16364915}. Note=Processing bodies (PB).
Disease Associations
Tissue Specificity Expressed in theca and granulosa cells in ovary, and in spermatids of the meiotic division part II and apical membrane of Sertoli cells in testis (at protein level). Also expressed in brain and mammary gland. {ECO:0000269PubMed:17533573}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR004443 YjeF N-terminal domain
IPR019050 FDF domain
PFAM PF03853
PF09532
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96F86
PhosphoSite PhosphoSite-Q96F86
TrEMBL H3BU87
UniProt Splice Variant
Entrez Gene 80153
UniGene Hs.96852
RefSeq
HUGO HGNC:26114
OMIM 609842
CCDS CCDS10267
HPRD 07954
IMGT
EMBL AC091230 AC100835 AF193058 AK024781 AK056339 BC011534 BC021271 CH471136
GenPept AAG22486 AAH11534 AAH21271 BAB15001 BAG51682 EAW99316 EAW99317 EAW99318 EAW99319