InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOXK1

Summary

InnateDB Protein

IDBP-7278.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXK1

Protein Name

forkhead box K1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000328720

InnateDB Gene

IDBG-7276 (FOXK1)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). {ECO:0000250UniProtKB:P42128}.

Subcellular Localization

Nucleus {ECO:0000255, ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node. {ECO:0000269PubMed:15289879}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007517	muscle organ development
GO:0030154	cell differentiation
GO:0030308	negative regulation of cell growth
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated