InnateDB Protein
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IDBP-727674.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CABYR
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Protein Name
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000462811
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InnateDB Gene
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IDBG-1684 (CABYR)
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Protein Structure
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Function |
May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.
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Subcellular Localization |
Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Localized to fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella.Isoform 1: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.Isoform 3: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.Isoform 5: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.
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Disease Associations |
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Tissue Specificity |
Expressed in elongating spermatids and spermatozoa (at protein level). Isoform 1 is expressed in testis. Isoform 3 and isoform 5 are also expressed in brain, pancreas and numerous brain tumors. {ECO:0000269PubMed:11820818, ECO:0000269PubMed:15752768, ECO:0000269PubMed:16139264}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003117
Dimerization-anchoring domain of cAMP-dependent protein kinase, regulatory subunit
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PFAM |
PF02197
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PRINTS |
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PIRSF |
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SMART |
SM00394
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TIGRFAMs |
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Modification |
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SwissProt |
O75952
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PhosphoSite |
PhosphoSite-O75952
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TrEMBL |
J3QQK7
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UniProt Splice Variant |
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Entrez Gene |
26256
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UniGene |
Hs.511983
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RefSeq |
XP_005258304
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HUGO |
HGNC:15569
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OMIM |
612135
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CCDS |
CCDS42420
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HPRD |
10806
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IMGT |
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EMBL |
AC090772
AF088868
AF295037
AF295038
AF295039
AF329634
AK313243
AY007205
BC011996
CH471088
HQ659768
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GenPept |
AAC35373
AAG01891
AAG17889
AAG17890
AAG17891
AAH11996
AAL56051
ADX30691
BAG36054
EAX01177
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