InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPC1

Summary

InnateDB Protein

IDBP-727580.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPC1

Protein Name

Synonyms

NPC;

Species

Homo sapiens

Ensembl Protein

ENSP00000467636

InnateDB Gene

IDBG-1600 (NPC1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008158	hedgehog receptor activity

Biological Process

GO:0007165	signal transduction
GO:0030301	cholesterol transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000731 Sterol-sensing domain
IPR003392 Patched
IPR004765 Niemann-Pick C type protein
IPR004869 Membrane transport protein, MMPL domain

PFAM

PF02460
PF03176

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B4DET3

UniProt Splice Variant

Entrez Gene

4864

UniGene

Hs.715623

RefSeq

HUGO

HGNC:7897

OMIM

607623

CCDS

HPRD

09622

IMGT

EMBL

AC010853 AC026634 AK293779

GenPept

BAG57194