InnateDB Protein
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IDBP-727352.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MYL12B
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Protein Name
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000463559
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InnateDB Gene
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IDBG-455 (MYL12B)
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Protein Structure
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Function |
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed in various hematopoietic cells. {ECO:0000269PubMed:11436981, ECO:0000269PubMed:18480596}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
19
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002048
EF-hand domain
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PFAM |
PF00036
PF13202
PF13405
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PRINTS |
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PIRSF |
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SMART |
SM00054
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TIGRFAMs |
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Modification |
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SwissProt |
O14950
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PhosphoSite |
PhosphoSite-O14950
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
103910
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UniGene |
Hs.594402
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RefSeq |
NP_001138417
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HUGO |
HGNC:29827
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OMIM |
609211
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CCDS |
CCDS11831
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HPRD |
10095
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IMGT |
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EMBL |
AB046614
AK291726
AY320408
BC004994
CH471113
D50372
D82058
U26162
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GenPept |
AAA67367
AAH04994
AAP73808
BAA23323
BAB62403
BAB88918
BAF84415
EAX01675
EAX01676
EAX01677
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