InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMAD2

Summary

InnateDB Protein

IDBP-727215.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMAD2

Protein Name

Synonyms

hMAD-2; hSMAD2; JV18; JV18-1; MADH2; MADR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000467075

InnateDB Gene

IDBG-3127 (SMAD2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 432 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	432 [view]
Protein-Protein	419 [view]
Protein-DNA	4 [view]
Protein-RNA	1 [view]
DNA-DNA	6 [view]
RNA-RNA	2 [view]
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007179	transforming growth factor beta receptor signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

InterPro

IPR001132 SMAD domain, Dwarfin-type
IPR003619 MAD homology 1, Dwarfin-type
IPR008984 SMAD/FHA domain
IPR013019 MAD homology, MH1
IPR019471 Interferon regulatory factor-3

PFAM

PF03166
PF03165
PF10401

PRINTS

PIRSF

SMART

SM00524
SM00523

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite