InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RPAP1

Summary

InnateDB Protein

IDBP-7176.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPAP1

Protein Name

RNA polymerase II associated protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000306123

InnateDB Gene

IDBG-7174 (RPAP1)

Protein Structure

UniProt Annotation

Function

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269PubMed:17643375}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0005488	binding

Biological Process

GO:0032774

RNA biosynthetic process

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR013929 RNA polymerase II-associated protein 1, C-terminal
IPR013930 RNA polymerase II-associated protein 1, N-terminal
IPR016024 Armadillo-type fold

PFAM

PF08620
PF08621

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BWH6

PhosphoSite