Version 5.4
Homo sapiens Protein: ERC1
Summary
InnateDB Protein IDBP-717168.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERC1
Protein Name
Synonyms Cast2; ELKS; ERC-1; RAB6IP2;
Species Homo sapiens
Ensembl Protein ENSP00000468263
InnateDB Gene IDBG-11681 (ERC1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
GO:0043522 leucine zipper domain binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007252 I-kappaB phosphorylation
GO:0007275 multicellular organismal development
GO:0015031 protein transport
GO:0042147 retrograde transport, endosome to Golgi
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0008385 IkappaB kinase complex
GO:0042734 presynaptic membrane
GO:0045202 synapse
Protein Structure and Domains
PDB ID
InterPro IPR009053 Prefoldin
IPR019018 Rab-binding domain FIP-RBD
IPR019323 CAZ complex, RIM-binding protein
PFAM PF09457
PF10174
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IUD2
PhosphoSite PhosphoSite-Q8IUD2
TrEMBL K7EKH8
UniProt Splice Variant
Entrez Gene 23085
UniGene Hs.704234
RefSeq NP_829884
HUGO HGNC:17072
OMIM 607127
CCDS CCDS8508
HPRD 06181
IMGT
EMBL AB015617 AB029004 AB053468 AB053469 AB053470 AB053471 AC004671 AC004672 AC004802 AC004803 AC004804 AC006561 AC092469 AK000148 AK092201 BC068006 BC132782 BC132784 BC150248 CH471116
GenPept AAH68006 AAI32783 AAI32785 AAI50249 BAA83033 BAA88763 BAA90975 BAC03827 BAC54107 BAC54108 BAC54109 BAC54110 EAW88932 EAW88934 EAW88936 EAW88938

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca