InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNA12

Summary

InnateDB Protein

IDBP-7132.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNA12

Protein Name

guanine nucleotide binding protein (G protein) alpha 12

Synonyms

gep; NNX3; RMP;

Species

Homo sapiens

Ensembl Protein

ENSP00000275364

InnateDB Gene

IDBG-7130 (GNA12)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. May play a role in the control of cell migration through the TOR signaling cascade. {ECO:0000269PubMed:22609986}.

Subcellular Localization

Membrane; Lipid-anchor.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	35 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0031752	D5 dopamine receptor binding
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007266	Rho protein signal transduction
GO:0007596	blood coagulation
GO:0008360	regulation of cell shape
GO:0010762	regulation of fibroblast migration
GO:0030154	cell differentiation
GO:0030168	platelet activation
GO:0032006	regulation of TOR signaling
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556	intracellular signal transduction
GO:0042493	response to drug
GO:0042733	embryonic digit morphogenesis

Cellular Component

GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0031526	brush border membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000469 G-protein alpha subunit, group 12
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011025 G protein alpha subunit, helical insertion
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00503
PF00025

PRINTS

PR00440
PR00318
PR00328

PIRSF

SMART

SM00275

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt