InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WHSC1

Summary

InnateDB Protein

IDBP-7116.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WHSC1

Protein Name

Wolf-Hirschhorn syndrome candidate 1

Synonyms

MMSET; NSD2; REIIBP; TRX5; WHS;

Species

Homo sapiens

Ensembl Protein

ENSP00000372344

InnateDB Gene

IDBG-7100 (WHSC1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0018024	histone-lysine N-methyltransferase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0009653	anatomical structure morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000313 PWWP domain
IPR001214 SET domain
IPR001841 Zinc finger, RING-type
IPR001965 Zinc finger, PHD-type
IPR003616 Post-SET domain
IPR006560 AWS domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger

PFAM

PF00855
PF00856
PF13639
PF14634
PF00628

PRINTS

PIRSF

SMART

SM00293
SM00317
SM00184
SM00249
SM00508
SM00570

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O96028