Version 5.4
Bos taurus Protein: SPE39
Summary
InnateDB Protein IDBP-699742.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPE39
Protein Name VPS33B-interacting protein
Synonyms C10H14orf133; SPE-39; SPE39; VIPAR;
Species Bos taurus
Ensembl Protein ENSBTAP00000027283
InnateDB Gene IDBG-646897 (SPE39)
Protein Structure
UniProt Annotation
Function Plays a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes. May play a role in epithelial polarization through stabilization of apical membrane protein content, possibly via the RAB11A-dependent apical recycling pathway. Also involved in direct or indirect transcriptional regulation of E-cadherin. May play a role in vesicular trafficking during spermatogenesis (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Early endosome {ECO:0000250}. Recycling endosome {ECO:0000250}. Late endosome {ECO:0000250}. Note=Colocalizes in clusters with VPS33B at cytoplasmic organelles. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0007283 spermatogenesis
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0030154 cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030897 HOPS complex
GO:0031410 cytoplasmic vesicle
GO:0055037 recycling endosome
Protein Structure and Domains
PDB ID
InterPro IPR019177 Golgin subfamily A member 5
PFAM PF09787
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A5D796
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 508872
UniGene Bt.57741
RefSeq NP_001091469
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140476
GenPept AAI40477

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca