Version 5.4
Bos taurus Protein: HIF1A
Summary
InnateDB Protein IDBP-699588.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIF1A
Protein Name hypoxia-inducible factor 1-alpha
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027885
InnateDB Gene IDBG-646757 (HIF1A)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 144 interaction(s) predicted by orthology.
Predicted by orthology
Total 144 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000989 transcription factor binding transcription factor activity
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0035035 histone acetyltransferase binding
GO:0035257 nuclear hormone receptor binding
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0051879 Hsp90 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001666 response to hypoxia
GO:0001755 neural crest cell migration
GO:0001837 epithelial to mesenchymal transition
GO:0001892 embryonic placenta development
GO:0001922 B-1 B cell homeostasis
GO:0001944 vasculature development
GO:0001947 heart looping
GO:0002052 positive regulation of neuroblast proliferation
GO:0002248 connective tissue replacement involved in inflammatory response wound healing
GO:0003151 outflow tract morphogenesis
GO:0003208 cardiac ventricle morphogenesis
GO:0006089 lactate metabolic process
GO:0006110 regulation of glycolytic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006879 cellular iron ion homeostasis
GO:0007165 signal transduction
GO:0007595 lactation
GO:0008542 visual learning
GO:0010468 regulation of gene expression
GO:0010573 vascular endothelial growth factor production
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0010634 positive regulation of epithelial cell migration
GO:0010870 positive regulation of receptor biosynthetic process
GO:0014850 response to muscle activity
GO:0019896 axon transport of mitochondrion
GO:0021502 neural fold elevation formation
GO:0021987 cerebral cortex development
GO:0030154 cell differentiation
GO:0030502 negative regulation of bone mineralization
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032007 negative regulation of TOR signaling
GO:0032364 oxygen homeostasis
GO:0032909 regulation of transforming growth factor beta2 production
GO:0032963 collagen metabolic process
GO:0035162 embryonic hemopoiesis
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042127 regulation of cell proliferation
GO:0042541 hemoglobin biosynthetic process
GO:0042593 glucose homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045926 negative regulation of growth
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046716 muscle cell cellular homeostasis
GO:0046886 positive regulation of hormone biosynthetic process
GO:0048514 blood vessel morphogenesis
GO:0048546 digestive tract morphogenesis
GO:0050790 regulation of catalytic activity
GO:0051216 cartilage development
GO:0051541 elastin metabolic process
GO:0060574 intestinal epithelial cell maturation
GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development
GO:0061298 retina vasculature development in camera-type eye
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070243 regulation of thymocyte apoptotic process
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0071347 cellular response to interleukin-1
GO:0071456 cellular response to hypoxia
GO:0071542 dopaminergic neuron differentiation
GO:2001054 negative regulation of mesenchymal cell apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031514 motile cilium
Protein Structure and Domains
PDB ID
InterPro IPR000014 PAS domain
IPR001321 Hypoxia-inducible factor-1 alpha
IPR001610 PAC motif
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013655 PAS fold-3
IPR013767 PAS fold
IPR014887 HIF-1 alpha, transactivation domain, C-terminal
IPR021537 Hypoxia-inducible factor, alpha subunit
PFAM PF13188
PF13426
PF00010
PF08447
PF00989
PF08778
PF11413
PRINTS PR01080
PIRSF
SMART SM00091
SM00086
SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A0JND0
UniProt Splice Variant
Entrez Gene 281814
UniGene Bt.4184
RefSeq NP_776764
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC126622 DAAA02029320
GenPept AAI26623

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca