InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BCL2L2

Summary

InnateDB Protein

IDBP-698578.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL2L2

Protein Name

Bcl-2-like protein 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000026248

InnateDB Gene

IDBG-645824 (BCL2L2)

Protein Structure

UniProt Annotation

Function

Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006915	apoptotic process
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0060011	Sertoli cell proliferation
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0031966	mitochondrial membrane
GO:0070062	extracellular vesicular exosome