InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HCN4

Summary

InnateDB Protein

IDBP-698364.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HCN4

Protein Name

hyperpolarization activated cyclic nucleotide-gated potassium channel 4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000023219

InnateDB Gene

IDBG-645641 (HCN4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005222	intracellular cAMP activated cation channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0002027	regulation of heart rate
GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0008016	regulation of heart contraction
GO:0035725	sodium ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport
GO:0071320	cellular response to cAMP
GO:0071321	cellular response to cGMP
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031226	intrinsic component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000595 Cyclic nucleotide-binding domain
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
IPR005821 Ion transport domain
IPR013621 Ion transport N-terminal
IPR018490 Cyclic nucleotide-binding-like

PFAM

PF00027
PF00520
PF08412

PRINTS

PR01463

PIRSF

SMART

SM00100

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt