Version 5.4
Bos taurus Protein: PTBP1
Summary
InnateDB Protein IDBP-698243.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTBP1
Protein Name Polypyrimidine tract-binding protein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000054889
InnateDB Gene IDBG-645533 (PTBP1)
Protein Structure
UniProt Annotation
Function Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
Predicted by orthology
Total 58 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0036002 pre-mRNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0033119 negative regulation of RNA splicing
GO:0048025 negative regulation of mRNA splicing, via spliceosome
GO:0051148 negative regulation of muscle cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
IPR006536 HnRNP-L/PTB/hephaestus splicing factor
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WN55
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282018
UniGene Bt.9031
RefSeq NP_776867
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF445640
GenPept AAL38169

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca