InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: OSTB

Summary

InnateDB Protein

IDBP-698025.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OSTB

Protein Name

Organic solute transporter subunit beta

Synonyms

OSTB; OSTBETA;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004864

InnateDB Gene

IDBG-645322 (OSTB)

Protein Structure

UniProt Annotation

Function

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006810	transport
GO:0015721	bile acid and bile salt transport
GO:0031647	regulation of protein stability
GO:0060050	positive regulation of protein glycosylation
GO:0070863	positive regulation of protein exit from endoplasmic reticulum
GO:0090314	positive regulation of protein targeting to membrane

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A0JNM1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

507185

UniGene

RefSeq

NP_001071335

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC126778

GenPept

AAI26779