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InnateDB Protein
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IDBP-697998.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ERO1L
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Protein Name
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ERO1-like protein alpha
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Synonyms
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ERO1-L;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000020878
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InnateDB Gene
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IDBG-645292 (ERO1L)
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Protein Structure
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| Function |
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5- trisphosphate receptor IP3R1 (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Lumenal side {ECO:0000250}. Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum. {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
10 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0003756
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protein disulfide isomerase activity
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GO:0005515
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protein binding
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GO:0015035
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protein disulfide oxidoreductase activity
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GO:0016491
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oxidoreductase activity
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GO:0016671
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oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
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| Biological Process |
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GO:0006915
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apoptotic process
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GO:0019471
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4-hydroxyproline metabolic process
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GO:0022417
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protein maturation by protein folding
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GO:0030198
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extracellular matrix organization
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GO:0030968
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endoplasmic reticulum unfolded protein response
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GO:0034976
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response to endoplasmic reticulum stress
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GO:0045454
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cell redox homeostasis
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GO:0050873
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brown fat cell differentiation
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GO:0051085
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chaperone mediated protein folding requiring cofactor
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GO:0051209
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release of sequestered calcium ion into cytosol
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GO:0055114
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oxidation-reduction process
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GO:0070059
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intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR007266
Endoplasmic reticulum oxidoreductin 1
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| PFAM |
PF04137
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| PRINTS |
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| PIRSF |
PIRSF017205
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
A5PJN2
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
100125317
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| UniGene |
Bt.91589
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| RefSeq |
NP_001096818
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| HUGO |
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
BC142179
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| GenPept |
AAI42180
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Version 5.4