Version 5.4
Bos taurus Protein: CXXC1
Summary
InnateDB Protein IDBP-697372.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXXC1
Protein Name CpG-binding protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000029172
InnateDB Gene IDBG-644715 (CXXC1)
Protein Structure
UniProt Annotation
Function Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000250}.
Subcellular Localization Nucleus speckle {ECO:0000250}. Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0045322 unmethylated CpG binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051568 histone H3-K4 methylation
Cellular Component
GO:0005634 nucleus
GO:0016363 nuclear matrix
GO:0016607 nuclear speck
GO:0035097 histone methyltransferase complex
GO:0048188 Set1C/COMPASS complex
Protein Structure and Domains
PDB ID
InterPro IPR001965 Zinc finger, PHD-type
IPR002857 Zinc finger, CXXC-type
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger
IPR022056 CpG binding protein, C-terminal
PFAM PF02008
PF00628
PF12269
PRINTS
PIRSF
SMART SM00249
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5EA28
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 511446
UniGene Bt.9994
RefSeq NP_001019688
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102763 BT020741
GenPept AAI02764 AAX08758

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca