InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NPC1

Summary

InnateDB Protein

IDBP-696544.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPC1

Protein Name

Niemann-Pick C1 protein

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020219

InnateDB Gene

IDBG-643938 (NPC1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008158	hedgehog receptor activity
GO:0015485	cholesterol binding

Biological Process

GO:0006486	protein glycosylation
GO:0006897	endocytosis
GO:0006914	autophagy
GO:0007165	signal transduction
GO:0007628	adult walking behavior
GO:0016242	negative regulation of macroautophagy
GO:0030301	cholesterol transport
GO:0031579	membrane raft organization
GO:0033344	cholesterol efflux
GO:0042493	response to drug
GO:0071383	cellular response to steroid hormone stimulus
GO:0071404	cellular response to low-density lipoprotein particle stimulus
GO:0090150	establishment of protein localization to membrane

Cellular Component

GO:0005576	extracellular region
GO:0005635	nuclear envelope
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031982	vesicle
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000731 Sterol-sensing domain
IPR003392 Patched
IPR004765 Niemann-Pick C type protein
IPR004869 Membrane transport protein, MMPL domain

PFAM

PF02460
PF03176

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B0JYK2

UniProt Splice Variant

Entrez Gene

286772

UniGene

Bt.7157

RefSeq

NP_777183

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC151276 DAAA02056610 DAAA02056611

GenPept

AAI51277