InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: KDR

Summary

InnateDB Protein

IDBP-694807.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDR

Protein Name

vascular endothelial growth factor receptor 2

Synonyms

flk-1; VEGFR2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000001038

InnateDB Gene

IDBG-642352 (KDR)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005021	vascular endothelial growth factor-activated receptor activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0038085	vascular endothelial growth factor binding

Biological Process

GO:0001541	ovarian follicle development
GO:0001570	vasculogenesis
GO:0001934	positive regulation of protein phosphorylation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001945	lymph vessel development
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0010595	positive regulation of endothelial cell migration
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016310	phosphorylation
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030097	hemopoiesis
GO:0030324	lung development
GO:0030335	positive regulation of cell migration
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0043129	surfactant homeostasis
GO:0043410	positive regulation of MAPK cascade
GO:0045165	cell fate commitment
GO:0045446	endothelial cell differentiation
GO:0045766	positive regulation of angiogenesis
GO:0046777	protein autophosphorylation
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048286	lung alveolus development
GO:0048469	cell maturation
GO:0048754	branching morphogenesis of an epithelial tube
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050927	positive regulation of positive chemotaxis
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
GO:0051894	positive regulation of focal adhesion assembly
GO:0055074	calcium ion homeostasis
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:2000352	negative regulation of endothelial cell apoptotic process

Cellular Component

GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045121	membrane raft
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR009136 Vascular endothelial growth factor receptor 2 (VEGFR2)
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF07679
PF07686
PF00047
PF08205

PRINTS

PR00109
PR01834

PIRSF

SMART

SM00220
SM00408
SM00409
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt