InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RIC8A

Summary

InnateDB Protein

IDBP-694327.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RIC8A

Protein Name

Synembryn-A

Synonyms

RIC8;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002646

InnateDB Gene

IDBG-641918 (RIC8A)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)- coupled receptor-mediated ERK activation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001944	vasculature development
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007369	gastrulation
GO:0008542	visual learning
GO:0009416	response to light stimulus
GO:0042074	cell migration involved in gastrulation
GO:0043547	positive regulation of GTPase activity
GO:0070586	cell-cell adhesion involved in gastrulation
GO:0071711	basement membrane organization

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR008376 Synembryn
IPR016024 Armadillo-type fold
IPR019318 Guanine nucleotide exchange factor, Ric8

PFAM

PF10165

PRINTS

PR01802

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5E9J8

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

521037

UniGene

Bt.3803

RefSeq

NP_001015627

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC118313 BT020922

GenPept

AAI18314 AAX08939