Version 5.4
Bos taurus Protein: UCHL1
Summary
InnateDB Protein IDBP-694281.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UCHL1
Protein Name Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000044075
InnateDB Gene IDBG-641874 (UCHL1)
Protein Structure
UniProt Annotation
Function Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Endoplasmic reticulum membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
Disease Associations
Tissue Specificity Neurons and cells of the diffuse neuroendocrine system and their tumors.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0008242 omega peptidase activity
GO:0016787 hydrolase activity
GO:0016874 ligase activity
GO:0031694 alpha-2A adrenergic receptor binding
GO:0043130 ubiquitin binding
Biological Process
GO:0002931 response to ischemia
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007409 axonogenesis
GO:0007412 axon target recognition
GO:0007628 adult walking behavior
GO:0008283 cell proliferation
GO:0016579 protein deubiquitination
GO:0019896 axon transport of mitochondrion
GO:0042755 eating behavior
GO:0043407 negative regulation of MAP kinase activity
GO:0048747 muscle fiber development
GO:0050905 neuromuscular process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase
PFAM PF01088
PRINTS PR00707
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P23356
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 514394
UniGene Bt.58848
RefSeq NP_001039637
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC111330
GenPept AAI11331

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca