Version 5.4
Bos taurus Protein: PDGFB
Summary
InnateDB Protein IDBP-694100.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDGFB
Protein Name platelet-derived growth factor subunit B
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000056346
InnateDB Gene IDBG-641707 (PDGFB)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008083 growth factor activity
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0042056 chemoattractant activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0048407 platelet-derived growth factor binding
Biological Process
GO:0001568 blood vessel development
GO:0001892 embryonic placenta development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002548 monocyte chemotaxis
GO:0003104 positive regulation of glomerular filtration
GO:0006468 protein phosphorylation
GO:0006929 substrate-dependent cell migration
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0010512 negative regulation of phosphatidylinositol biosynthetic process
GO:0010544 negative regulation of platelet activation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014911 positive regulation of smooth muscle cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030031 cell projection assembly
GO:0030036 actin cytoskeleton organization
GO:0030335 positive regulation of cell migration
GO:0030336 negative regulation of cell migration
GO:0031954 positive regulation of protein autophosphorylation
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0038001 paracrine signaling
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045740 positive regulation of DNA replication
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045840 positive regulation of mitosis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048146 positive regulation of fibroblast proliferation
GO:0048514 blood vessel morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0051781 positive regulation of cell division
GO:0060326 cell chemotaxis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071363 cellular response to growth factor stimulus
GO:0071456 cellular response to hypoxia
GO:0072126 positive regulation of glomerular mesangial cell proliferation
GO:0072255 metanephric glomerular mesangial cell development
GO:0072262 metanephric glomerular mesangial cell proliferation involved in metanephros development
GO:0072264 metanephric glomerular endothelium development
GO:0072593 reactive oxygen species metabolic process
GO:0090280 positive regulation of calcium ion import
GO:1900127 positive regulation of hyaluronan biosynthetic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000591 positive regulation of metanephric mesenchymal cell migration
Cellular Component
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000072 PDGF/VEGF domain
IPR006782 Platelet-derived growth factor, N-terminal
IPR029034 Cystine-knot cytokine
PFAM PF00341
PF04692
PRINTS
PIRSF
SMART SM00141
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q58D48
UniProt Splice Variant
Entrez Gene 540106
UniGene Bt.97627
RefSeq NP_001017953
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151383 BT021749 DAAA02014679 DAAA02014680
GenPept AAI51384 AAX46596

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca