Version 5.4
Bos taurus Protein: CPPED1
Summary
InnateDB Protein IDBP-689066.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPPED1
Protein Name calcineurin-like phosphoesterase domain-containing protein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000007071
InnateDB Gene IDBG-637080 (CPPED1)
Protein Structure
UniProt Annotation
Function Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0008152 metabolic process
GO:0016311 dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR029052 Metallo-dependent phosphatase-like
PFAM PF00149
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q58DC0
PhosphoSite PhosphoSite-
TrEMBL M5FMU5
UniProt Splice Variant
Entrez Gene 537938
UniGene Bt.39535
RefSeq NP_001026941
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133400 BT021677 GJ062847
GenPept AAI33401 AAX46524 DAA15608

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca