InnateDB Protein
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IDBP-689055.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SMARCB1
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Protein Name
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SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000013170
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InnateDB Gene
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IDBG-637072 (SMARCB1)
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Protein Structure
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Function |
Core component of the BAF (SWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 128 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
128 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006939
SNF5/SMARCB1/INI1
IPR017393
SWI/SNF chromatin-remodeling complex, component hSNF5/Ini1
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PFAM |
PF04855
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PRINTS |
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PIRSF |
PIRSF038126
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5BIN2
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q29RY5
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UniProt Splice Variant |
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Entrez Gene |
537412
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UniGene |
Bt.4638
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RefSeq |
NP_001035647
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC113345
BC133572
BT021192
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GenPept |
AAI13346
AAI33573
AAX31374
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