InnateDB Protein
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IDBP-6863.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RHBDF1
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Protein Name
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rhomboid 5 homolog 1 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000262316
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InnateDB Gene
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IDBG-6861 (RHBDF1)
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Protein Structure
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Function |
Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration. {ECO:0000269PubMed:15965977, ECO:0000269PubMed:18524845, ECO:0000269PubMed:18832597, ECO:0000269PubMed:21439629}.
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Subcellular Localization |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Predominantly localized in the endoplasmic reticulum membrane.
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Disease Associations |
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Tissue Specificity |
Highly expressed in cerebellum, cerebrum, heart, skeletal muscle, placenta, pancreatic islet and testis. Detected at lower levels in colon, kidney, small intestine and lung. {ECO:0000269PubMed:15965977, ECO:0000269PubMed:8318735}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR022241
Rhomboid serine protease
IPR022764
Peptidase S54, rhomboid domain
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PFAM |
PF12595
PF01694
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96CC6
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PhosphoSite |
PhosphoSite-Q96CC6
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TrEMBL |
F6XBT0
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UniProt Splice Variant |
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Entrez Gene |
64285
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UniGene |
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RefSeq |
NP_071895
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HUGO |
HGNC:20561
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OMIM |
614403
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CCDS |
CCDS32344
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HPRD |
07027
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IMGT |
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EMBL |
AE006462
AK026010
AK291177
BC014425
CH471112
DQ431198
M99624
Z69719
Z69720
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GenPept |
AAA02490
AAH14425
AAK61212
ABD95905
BAB15318
BAF83866
CAI95608
CAM26658
EAW85873
EAW85876
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