Version 5.4
Bos taurus Protein: SLC25A11
Summary
InnateDB Protein IDBP-686005.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC25A11
Protein Name Mitochondrial 2-oxoglutarate/malate carrier protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000035103
InnateDB Gene IDBG-634241 (SLC25A11)
Protein Structure
UniProt Annotation
Function Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.
Subcellular Localization Mitochondrion inner membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Heart, liver and brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006810 transport
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain
PFAM PF00153
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P22292
PhosphoSite PhosphoSite-
TrEMBL A5D954
UniProt Splice Variant
Entrez Gene 282523
UniGene Bt.27871
RefSeq NP_777096
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142283 BC146129 BT020806 BT030473 M58703 M60662 X66115
GenPept AAA30671 AAA30672 AAI42284 AAI46130 AAX08823 ABQ12913 CAA46906

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca