InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HSPH1

Summary

InnateDB Protein

IDBP-681958.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSPH1

Protein Name

Heat shock protein 105 kDa

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000006600

InnateDB Gene

IDBG-630492 (HSPH1)

Protein Structure

UniProt Annotation

Function

Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0043014	alpha-tubulin binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006950	response to stress
GO:0051085	chaperone mediated protein folding requiring cofactor

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005874	microtubule
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004753 Cell shape determining protein MreB/Mrl
IPR013126 Heat shock protein 70 family
IPR029047 Heat shock protein 70kD, peptide-binding domain
IPR029048 Heat shock protein 70kD, C-terminal domain

PFAM

PF06723
PF00012

PRINTS

PR01652
PR00301

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0IIM3