Version 5.4
Bos taurus Protein: SLC1A3
Summary
InnateDB Protein IDBP-681703.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC1A3
Protein Name Excitatory amino acid transporter 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000024287
InnateDB Gene IDBG-630261 (SLC1A3)
Protein Structure
UniProt Annotation
Function Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005313 L-glutamate transmembrane transporter activity
GO:0005314 high-affinity glutamate transmembrane transporter activity
GO:0005515 protein binding
GO:0015293 symporter activity
GO:0016595 glutamate binding
GO:0016597 amino acid binding
GO:0017153 sodium:dicarboxylate symporter activity
Biological Process
GO:0006536 glutamate metabolic process
GO:0006537 glutamate biosynthetic process
GO:0006810 transport
GO:0006835 dicarboxylic acid transport
GO:0007605 sensory perception of sound
GO:0009416 response to light stimulus
GO:0009449 gamma-aminobutyric acid biosynthetic process
GO:0009611 response to wounding
GO:0010035 response to inorganic substance
GO:0015813 L-glutamate transport
GO:0021545 cranial nerve development
GO:0031223 auditory behavior
GO:0042493 response to drug
GO:0043200 response to amino acid
GO:0046677 response to antibiotic
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0050806 positive regulation of synaptic transmission
GO:0050885 neuromuscular process controlling balance
GO:0051938 L-glutamate import
GO:0055085 transmembrane transport
GO:0070779 D-aspartate import
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043205 fibril
Protein Structure and Domains
PDB ID
InterPro IPR001991 Sodium:dicarboxylate symporter
PFAM PF00375
PRINTS PR00173
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P46411
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282354
UniGene Bt.361
RefSeq NP_777025
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120125 D82056
GenPept AAI20126 BAA11527

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca