InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: WRN

Summary

InnateDB Protein

IDBP-680293.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WRN

Protein Name

Werner syndrome, RecQ helicase-like

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000028778

InnateDB Gene

IDBG-628918 (WRN)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0000403	Y-form DNA binding
GO:0000405	bubble DNA binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003824	catalytic activity
GO:0004003	ATP-dependent DNA helicase activity
GO:0004386	helicase activity
GO:0004527	exonuclease activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008408	3'-5' exonuclease activity
GO:0009378	four-way junction helicase activity
GO:0016787	hydrolase activity
GO:0016887	ATPase activity
GO:0016987	sigma factor activity
GO:0030145	manganese ion binding
GO:0032403	protein complex binding
GO:0042803	protein homodimerization activity
GO:0043138	3'-5' DNA helicase activity
GO:0043140	ATP-dependent 3'-5' DNA helicase activity
GO:0051880	G-quadruplex DNA binding

Biological Process

GO:0000723	telomere maintenance
GO:0000731	DNA synthesis involved in DNA repair
GO:0001302	replicative cell aging
GO:0006139	nucleobase-containing compound metabolic process
GO:0006259	DNA metabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006302	double-strand break repair
GO:0006310	DNA recombination
GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0006979	response to oxidative stress
GO:0007569	cell aging
GO:0009267	cellular response to starvation
GO:0010225	response to UV-C
GO:0010259	multicellular organismal aging
GO:0031297	replication fork processing
GO:0032066	nucleolus to nucleoplasm transport
GO:0040009	regulation of growth rate
GO:0042981	regulation of apoptotic process
GO:0044237	cellular metabolic process
GO:0051345	positive regulation of hydrolase activity
GO:0071480	cellular response to gamma radiation
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005813	centrosome
GO:0032389	MutLalpha complex

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR002121 HRDC domain
IPR002562 3\'-5\' exonuclease domain
IPR004589 DNA helicase, ATP-dependent, RecQ type
IPR010997 HRDC-like
IPR011545 DEAD/DEAH box helicase domain
IPR012337 Ribonuclease H-like domain
IPR013324 RNA polymerase sigma factor, region 3/4
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR018982 RQC domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00570
PF01612
PF00270
PF09382

PRINTS

PIRSF

SMART

SM00490
SM00341
SM00474
SM00487
SM00956

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite