InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAC2

Summary

InnateDB Protein

IDBP-6501.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAC2

Protein Name

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

Synonyms

EN-7; Gx; HSPC022; p21-Rac2;

Species

Homo sapiens

Ensembl Protein

ENSP00000249071

InnateDB Gene

IDBG-6499 (RAC2)

Protein Structure

UniProt Annotation

Function

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. {ECO:0000269PubMed:1660188}.

Subcellular Localization

Cytoplasm. Note=Membrane-associated when activated.

Disease Associations

Neutrophil immunodeficiency syndrome (NEUID) [MIM:608203]: An immunodeficiency syndrome due to defective neutrophils. Affected individuals present with leukocytosis, neutrophilia, severe recurrent bacterial infections and poor wound healing. {ECO:0000269PubMed:10758162}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Hematopoietic specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	38 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0006935	chemotaxis
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0010310	regulation of hydrogen peroxide metabolic process
GO:0015031	protein transport
GO:0030031	cell projection assembly
GO:0030036	actin cytoskeleton organization
GO:0030168	platelet activation
GO:0045087	innate immune response (InnateDB)
GO:0045453	bone resorption
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0060263	regulation of respiratory burst

Cellular Component

GO:0005622	intracellular
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF08477

PRINTS

PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt