InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL2RB

Summary

InnateDB Protein

IDBP-6420.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL2RB

Protein Name

interleukin 2 receptor, beta

Synonyms

CD122; IL15RB; P70-75;

Species

Homo sapiens

Ensembl Protein

ENSP00000216223

InnateDB Gene

IDBG-6418 (IL2RB)

Protein Structure

UniProt Annotation

Function

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	44 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004911	interleukin-2 receptor activity
GO:0005515	protein binding
GO:0019976	interleukin-2 binding

Biological Process

GO:0006461	protein complex assembly
GO:0007165	signal transduction
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0038110	interleukin-2-mediated signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)