InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pspc1

Summary

InnateDB Protein

IDBP-620317.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pspc1

Protein Name

paraspeckle protein 1

Synonyms

5730470C09Rik; AI327109; AI449052; PSP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133038

InnateDB Gene

IDBG-167851 (Pspc1)

Protein Structure

UniProt Annotation

Function

Together with NONO, required for the formation of nuclear paraspeckles. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. {ECO:0000269PubMed:16641145, ECO:0000269PubMed:22966205}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Note=In punctate subnuclear structures localized adjacent to nuclear splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycle between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps. {ECO:0000250}.Isoform 1: Nucleus matrix. Cytoplasm. Nucleus speckle {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is strongly expressed in testis (leptoten spermatocytes, round spematids and Sertoli cells) and moderately in cerebrum, cerebellum, lung, spleen and ovary (at protein level). Isoform 2 is strongly expressed in kidney and moderately in salivary gland (at protein level). {ECO:0000269PubMed:15140795, ECO:0000269PubMed:16641145}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016363	nuclear matrix
GO:0016607	nuclear speck
GO:0042382	paraspeckles

Protein Structure and Domains

PDB ID

MGI:1913895

InterPro

IPR000504 RNA recognition motif domain
IPR012975 NOPS

PFAM

PF00076
PF08075

PRINTS

PIRSF

SMART

SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R326

PhosphoSite

PhosphoSite-Q8R326

TrEMBL

UniProt Splice Variant

Entrez Gene

66645

UniGene

Mm.412298

RefSeq

MGI ID

MGI Symbol

Pspc1

OMIM

CCDS

HPRD

IMGT

EMBL

AK011272 AK017689 AK150823 AK160722 BC026772

GenPept

AAH26772 BAB27509 BAB30876 BAE29885 BAE35969