InnateDB Protein
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IDBP-620141.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hnrnpc
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Protein Name
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heterogeneous nuclear ribonucleoprotein C
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Synonyms
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AL022939; D14Wsu171e; hnrnp-C; hnRNPC1; hnRNPC2; Hnrpc; Hnrpc1; Hnrpc2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000133052
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InnateDB Gene
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IDBG-158143 (Hnrnpc)
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Protein Structure
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Function |
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Note=Component of ribonucleosomes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 121 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
121 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:107795
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InterPro |
IPR000504
RNA recognition motif domain
IPR017347
Heterogeneous nuclear ribonucleoprotein C, Raly
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PFAM |
PF00076
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PRINTS |
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PIRSF |
PIRSF037992
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Z204
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PhosphoSite |
PhosphoSite-Q9Z204
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
15381
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UniGene |
Mm.473169
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RefSeq |
NP_001164453
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MGI ID |
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MGI Symbol |
Hnrnpc
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OMIM |
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CCDS |
CCDS36917
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HPRD |
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IMGT |
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EMBL |
AF095257
AF095258
AK011336
AK012633
AK019958
AK088245
AK088678
AK089061
AK166590
AK168802
BC004706
BC095922
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GenPept |
AAD03717
AAD19892
AAH04706
AAH95922
BAB27553
BAB28370
BAB31934
BAC40233
BAC40499
BAC40728
BAE38877
BAE40632
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